Imiti myinshi yimiti ikoreshwa mubinini, granule, ifu, nuburyo bwamazi.Muri rusange, igishushanyo mbonera kiri muburyo bwerekanwe abarwayi kumira cyangwa guhekenya neza imiti.Nyamara, cyane cyane abarwayi bakuze n’abana bafite ikibazo cyo guhekenya cyangwa kumira dosiye zikomeye.4 Kubwibyo, abana benshi ndetse nabasaza ntibashaka gufata iyi dosiye ikomeye kubera gutinya guhumeka.Kumenagura ibinini (ODTs) byagaragaye kugirango bikemuke.Nyamara, kubantu bamwe barwayi, ubwoba bwo kumira dosiye ihamye (tablet, capsule), hamwe ningaruka zo guhumeka bikomeza nubwo igihe gito cyo gusenyuka / gusenyuka.Sisitemu yo gutanga umunwa (OTF) uburyo bwo gutanga ibiyobyabwenge nubundi buryo bwiza muri ibi bihe.Bioavailable yo mu kanwa k'imiti myinshi ntabwo ihagije kubera enzymes, ibisanzwe byambere-metabolism, na pH yigifu.Imiti isanzwe yatanzwe kubabyeyi kandi yerekanye ko abarwayi bubahiriza.Ibihe nkibi byafunguye inzira inganda zimiti kugirango zitezimbere ubundi buryo bwo gutwara ibiyobyabwenge hifashishijwe firime zidakwirakwizwa / zishonga mumunwa.Gutinya kurohama, bishobora kuba ibyago na ODTs, byahujwe naya matsinda y’abarwayi.Iseswa ryihuse / gusenyuka kwa sisitemu yo gutanga imiti ya OTF nuburyo bwiza bwo guhitamo ODT kubarwayi bafite ubwoba bwo guhumeka.Iyo bishyizwe ku rurimi, OTF ihita itose n'amacandwe.Nkigisubizo, baratatanye kandi / cyangwa barashonga kugirango barekure imiti ya sisitemu na / cyangwa iyinjizwa ryaho.
Gusenya mu kanwa / gusohora firime cyangwa imirongo bishobora gusobanurwa gutya: “Izi ni uburyo bwo gutanga ibiyobyabwenge bahita barekura ibiyobyabwenge mu gushonga cyangwa kwizirika muri mucosa hamwe n'amacandwe mu masegonda make kubera ko birimo polymer zishonga amazi iyo zashyizwe mu cyuho cyo mu kanwa cyangwa ku rurimi ”.Mucosa ya sublingual ifite membrane ihindagurika cyane kubera imiterere yayo yoroheje kandi ihindagurika cyane.Kubera aya maraso yihuta, atanga bioavailable nziza cyane.Kongera imbaraga za bioavailability iterwa no kureka ingaruka zambere-pass kandi uburyo bwiza bwo gutembera biterwa no gutembera kwamaraso menshi no gutembera kwa lymphatike.Byongeye kandi, mucosa yo mu kanwa ninzira nziza kandi ihitamo uburyo bwo gutanga imiti itunganijwe kubera ubuso bunini kandi byoroshye kubisaba kwinjizwa.6 Muri rusange, OTF irangwa nkigice cyoroshye kandi cyoroshye cya polymer, hamwe na plasitike irimo cyangwa idafite ibirimo.Bashobora kuvugwa ko bidahungabanya kandi byemerwa n’abarwayi, kuko binanutse kandi byoroshye mu miterere yabyo.Filime ntoya ni sisitemu ya polymeric itanga byinshi mubisabwa biteganijwe muri sisitemu yo gutanga ibiyobyabwenge.Mu bushakashatsi, firime zoroheje zerekanye ubushobozi bwazo nko kunoza ingaruka zambere zibiyobyabwenge nigihe bimara, kugabanya inshuro zo kunywa, no kongera imikorere yibiyobyabwenge.Hamwe na tekinoroji yoroheje, birashobora kuba byiza gukuraho ingaruka mbi zibiyobyabwenge no kugabanya metabolisme isanzwe igurwa na enzymes za proteolyique.Filime nziza cyane igomba kuba ifite ibintu byifuzwa bya sisitemu yo gutanga ibiyobyabwenge, nkubushobozi bukwiye bwo gupakira ibiyobyabwenge, gutatanya vuba / gusesa, cyangwa kumara igihe kirekire no gushishoza neza.Na none, bigomba kuba bidafite ubumara, ibinyabuzima bishobora kubangikanywa na biocompatible.
Nk’uko Ikigo cy’Abanyamerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) kibitangaza ngo OTF isobanurwa ngo “harimo kimwe mu bintu byinshi cyangwa byinshi bikoreshwa mu bya farumasi (APIs), umurongo woroshye kandi utavunika ushyirwa ku rurimi mbere yo kunyura mu nzira ya gastrointestinal, ugamije gusenyuka vuba cyangwa gusenyuka mu macandwe ”.Icya mbere cyateganijwe OTF ni Zuplenz (Ondansetron HCl, 4-8 mg) kandi cyemejwe mu 2010. Suboxon (buprenorphine na naloxan) yahise akurikira nkuko iya kabiri yabyemeje.Ibarurishamibare ryerekana ko abarwayi bane kuri batanu bahitamo gusohora mu kanwa / gusibanganya dosiye ku buryo bwa dosiye gakondo yo mu kanwa. , allergique reaction, asima, indwara zo munda, ububabare, kuniha, ibibazo byo gusinzira, hamwe na vitamine nyinshi, nibindi. OTF irahari kandi ikomeje kwiyongera.13 Filime zo mu kanwa zishonga vuba zifite ibyiza byinshi kurenza izindi dosiye zikomeye, nko guhinduka no kongera imikorere ya API.Na none, firime zo mu kanwa zifite gusesa no gusenyuka hamwe n'amazi make y'amacandwe mugihe kitarenze umunota umwe ugereranije na ODTs.1
OTF igomba kugira ibintu byiza bikurikira
-Bigomba kuryoha
-Ibiyobyabwenge bigomba kwihanganira ubushuhe cyane kandi bigashonga mumacandwe
-Bigomba kugira ubukana bukwiye
-Bigomba kuba ionion mumyanya yo mu kanwa pH
-Bigomba gushobora kwinjira mumitsi yo mu kanwa
-Bigomba kuba bifite ingaruka zihuse
Ibyiza bya OTF kurenza izindi fomu
-Ibikorwa
-Ntabwo bisaba gukoresha amazi
-Bishobora gukoreshwa neza nubwo kubona amazi bidashoboka (nkurugendo)
-Nta kibazo cyo guhumeka
-Gutezimbere umutekano
-Byoroshye gusaba
-Gukoresha byoroshye abarwayi bo mumutwe kandi badahuye
-Hari bike cyangwa ntagisigara mumunwa nyuma yo kubisaba
-Byerekana inzira ya gastrointestinal bityo bikongera bioavailability
-Gabanya urugero n'ingaruka nke
-Bitanga dosiye yukuri iyo ugereranije na feri ya dosiye
-Ntabwo ukeneye gupima, ningaruka zingenzi muburyo bwa dosiye
-Gusiga ibyiyumvo byiza mumunwa
-Gutanga ingaruka zihuse mubihe bisaba gutabarwa byihutirwa, urugero, ibitero bya allergique nka asima n'indwara zo munda
-Yongera igipimo cyo kwinjiza nubunini bwibiyobyabwenge
-Gutanga bioavailable yimiti igabanya amazi make, cyane cyane mugutanga ubuso bunini mugihe ushonga vuba
-Ntabwo ibuza imirimo isanzwe nko kuvuga no kunywa
-Gutanga imiti ifite ibyago byinshi byo guhungabana mumitsi yigifu
-Afite isoko ryaguka nibicuruzwa bitandukanye
-Bishobora gutezwa imbere bigashyirwa ku isoko mu mezi 12-16
Iyi ngingo yavuye kuri enterineti, nyamuneka hamagara kubihohotera!
©Uburenganzira2021 Turk J Pharm Sci, Yanditswe na Galenos Inzu y'Ubwanditsi.
Igihe cyo kohereza: Ukuboza-01-2021